Igor

John Cusack

as

Igor (voice)

Myleene Klass

as

Dr. Holzwurm (...

Robin Walsh

as

Dr. Holzwurm's...

Matt McKenna

as

Dr. Herzschlag...

John Cleese

as

Dr. Glickenste...

Steve Buscemi

as

Scamper (voice)

Sean Hayes

as

Brain (voice)

Eddie Izzard

as

Dr. Schadenfre...

Jay Leno

as

King Malbert (...

Jennifer Cooli...

as

Jaclyn / Heidi...

Molly Shannon

as

Eva (voice)

James Lipton

as

Himself

Christian Slat...

as

Dr. Schadenfre...

Arsenio Hall

as

Carl Cristall ...

Jess Harnell

as

Announcer / Ro...

Zoë Bright

as

Blind Woman / ...

Sophia Eraklis

as

Blind Orphan #...

A. Cheron Hall

as

Blind Orphan #...

Alexander Leon...

as

Blind Orphan #...

Michael Leondis

as

Blind Orphan #...

Nicole Leondis

as

Blind Orphan #...

Juliana Leondis

as

Blind Orphan #...

Robin Tisserand

as

Blind Orphan #...

Paul Vogt

as

Buzz Offmann (...

Frank Welker

as

Animals' vocal...