Vixen is the nymphomaniacal spouse of a bush pilot who owns a fishing lodge in British Columbia. While her husband, Tom, is away, Vixen frolics in the woods with a Canadian Mountie and then returns to the lodge to tease her motorcyclist brother Jud and insult his black friend Niles, a draft dodger from the States. Clint Ramsey has to leave his job working at Martin Bormann's gas station and flee after his wife is murdered by psycho cop Harry Sledge, who tries to pin the murder on Clint. Crossing America, Clint gets sexually harassed on all sides by various voluptuous nymphomaniacs, and it all ends in a literally explosive climax. The bedroom habits in the small town of Rio Dio, Texas are seen through the experiences of a junkyard worker Lamar Shedd and his sexually insatiable wife Lavonia. While Lamar tries several "cures" for his unusual sexual tastes, Lavonia seeks out sex with various partners around town.